Cayuse 424 is an easy-to-use web application created specifically to simplify the creation, review, approval, and electronic submission of federal grant proposals. Cayuse 424 helps organizations of all sizes accelerate proposal development, reduce pre-award overhead and improve the quality and accuracy of sponsored funding proposals. With Cayuse 424, proposal development becomes substantially easier than with any other commercial or free technology. It was designed with the belief that there should be as few barriers as possible between scientific research and its federal funding sources.